The present utility model is a computer-implemented system for hybrid wireless guitar effects activation which enables seamless integration and control of both physical and virtual guitar effects. The system comprises a guitar equipped with a transceiver module to transmit audio signals and a switching assembly featuring multiple switches. These switches are managed by a microcontroller that processes electrical control signals, which are wirelessly transmitted to a receiving activation assembly. The receiving activation assembly includes transceivers, microcontrollers, and latching relays to activate a chain of guitar pedal effects. It also supports hybrid mode wherein physical effects integrate with virtual effects activated through a computing device connected via an audio interface. The system is powered by a rechargeable battery with a step-up converter. This innovative design enhances flexibility and user experience by allowing musicians to wirelessly switch between or combine traditional pedal effects and virtual effects with precision and ease.