Application Type
Invention
Application SubType
Invention PCT
(10) Registration Number and Date
Status
893/${sta2}
(180) Expiration Date
(20) Filing Number and Date
PH 1/2024/552217 2023.03.30
(40) Publication Number and Date
PH 1/2024/552217
U3
2025.06.23
(86) PCT Filing Number and Date
(87) PCT Publication Number and Date
(85) National Entry Date
(30) Priority Details
(51) IPC Classes
(71/73) Applicant
(74) Representative Name
(EN) Hechanova & Co., Inc. : G/F & 4/F Salustiana D. Ty Tower, 104 Paseo de Roxas, Legazpi Village, Makati City
(54) Title
(EN) BISPECIFIC ANTIBODIES COMPRISING AN NRP1 BINDING DOMAIN AND METHODS OF USE THEREOF
(57) Abstract
(EN)
The present disclosure provides bispccific antibodies, and compositions and methods of treating cancer incorporating said bispecific antibodies. The bispecific antibodies include a polypeptide comprising an EGFR-binding domain and a neuropilin (NRP1)- specific binding domain at the C-terminal end. Monoclonal antibodies that specifically bind NRP1 are also provided.
(58) Citations